Bondarenko I.O. Neurohumoral regulation changes according to heart rate va-
riability in patients with moderate and severe stage of chronic obstructive
pulmonary disease. – Manuscript.

Dissertation  for  the  degree  of  candidate medical  sciences by specialty 
14.01.27 - pulmonology. State department “National Institute of Phthisiology
and Pulmonology of Academy of Medical Science of Ukraine named by F.G.Yanov-
skiy”, Kyiv, 2008.

The work covers the problems of investigating the clinical parameters, indi-
ces of external respiration function (ERF) and heart rate variability  (HRV)
in  patients  with  chronic  obstructive  pulmonary disease (COPD) against a 
background of the basic  herapy depending on  the  gender, age,  duration of 
the disease,  term  of  smoking and initial level of total power of HRV spec-
trum. The study involved 105 patients with COPD in the stage of remission (36
female and 69 male) aged (60,4 ± 9,6) with COPD lasting (10,1 ± 5,3) years.

The complex investigation demonstrated efficacy of the long-term basic thera-
py for COPD. Initial variations in the  degree of  HRV parameters in patients 
with COPD II – III stage were found. They characterized by total power decrea-
sed and increased level of low to high relation. More significant disturbances
of  HRV  were found in males, elderly patients and in smokers. The  importance 
of HRV technology for the state of regulatory systems control in patients with 
chronic obstructive pulmonary disease on the stages of basic  therapy was pro-
ven. The former can be used in the practical work of the clinicians to improve
the quality of diagnosis, therapy and prognosis of COPD course.

Keywords: chronic obstructive pulmonary disease, heart rate variability,
spirometry, basis therapy